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Details on Person IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS

Class:Id	Reaction:1793186
_displayName	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS
_doRelease	TRUE
_timestamp	2025-03-07 10:25:30
authored	[InstanceEdit:1793189] Jassal, B, 2011-10-21
catalystActivity	[CatalystActivity:1678683] L-iduronidase activity of IDUA [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1793189] Jassal, B, 2011-10-21
edited	[InstanceEdit:1793189] Jassal, B, 2011-10-21
goBiologicalProcess	[GO_BiologicalProcess:21608] dermatan sulfate proteoglycan catabolic process
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [SimpleEntity:2105025] IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:1678628] Human alpha-L-iduronidase: cDNA isolation and expression [LiteratureReference:2105003] Identification of mutations in the alpha-L-iduronidase gene (IDUA) that cause Hurler and Scheie syndromes
modified	[InstanceEdit:1793192] Jassal, B, 2011-10-21 [InstanceEdit:1793232] Jassal, B, 2011-10-21 [InstanceEdit:1971508] Jassal, B, 2011-11-04 [InstanceEdit:2024092] Jassal, B, 2011-12-14 [InstanceEdit:2065265] Jassal, B, 2012-01-20 [InstanceEdit:2105013] Jassal, B, 2012-02-09 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:9036076] Jassal, Bijay, 2018-01-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
name	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS
output	[SimpleEntity:1678617] aldehydo-L-iduronic acid [lysosomal lumen] [SimpleEntity:2104993] CHEBI:63868 chain [lysosomal lumen]
precedingEvent	[Reaction:2105001] HEXA cleaves the terminal GalNAc from DS [Homo sapiens] [Reaction:1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) [Homo sapiens] [Reaction:9638075] HEXB cleaves the terminal GalNAc from DS [Homo sapiens] [Reaction:1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294962] R-HSA-1793186.4
summation	[Summation:2105008] The lysosomal enzyme alpha-L-iduronidase (IDUA) hydrolyzes t...
(hasEvent)	[Pathway:2024101] CS/DS degradation [Homo sapiens]
(normalReaction)	[FailedReaction:9036041] Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788480] Update Tracker - [Reaction:1793186] IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS - v42:[modifyText]
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No pathways have been reviewed or authored by IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS (1793186)