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Details on Person TDG is a G/T mismatch-specific thymine DNA glycosylase that ...
| Class:Id | Summation:179197 |
|---|---|
| _displayName | TDG is a G/T mismatch-specific thymine DNA glycosylase that ... |
| _timestamp | 2014-12-19 19:22:32 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5637480] Orlic-Milacic, Marija, 2014-11-10 [InstanceEdit:5637505] Orlic-Milacic, Marija, 2014-11-10 [InstanceEdit:5658605] Orlic-Milacic, Marija, 2014-12-19 |
| text | TDG is a G/T mismatch-specific thymine DNA glycosylase that recognizes and binds thymine mispaired with guanine. G:T mispairs occur when 5-methylcytosine deaminates into thymine. Besides being mutagenic, conversion of 5-methylcytosine into thymine may also affect gene expression by changing the DNA methylation pattern. TDG shows a preference for G:T mispairs in CpG islands (Neddermann and Jiricny 1993, Neddermann et al. 1996). TDG ortholog knockout is embryonic lethal in mice, where it is implicated in protection of CpG islands from hypermethylation and active demethylation of tissue-specific developmentally and homornally regulated promoters and enhancers (Cortellino et al. 2011). |
| (summation) | [Reaction:110158] TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine [Homo sapiens] |
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No pathways have been reviewed or authored by TDG is a G/T mismatch-specific thymine DNA glycosylase that ... (179197)
