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Details on Person Substrate specificity of cyclin B:Cdk1 complexes is primaril...

Class:IdSummation:179076
_displayNameSubstrate specificity of cyclin B:Cdk1 complexes is primaril...
_timestamp2008-02-26 01:04:35
created[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
literatureReference[LiteratureReference:213386] The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus
[LiteratureReference:170052] MPF localization is controlled by nuclear export
[LiteratureReference:213362] Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint
[LiteratureReference:170214] Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
[LiteratureReference:170205] Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal
[LiteratureReference:170253] Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
[LiteratureReference:213367] Temporal and spatial control of cyclin B1 destruction in metaphase
[LiteratureReference:213384] Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
[LiteratureReference:213359] Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
modified[InstanceEdit:213369] Matthews, L, 2008-02-26 00:56:34
textSubstrate specificity of cyclin B:Cdk1 complexes is primarily conferred by their subcellular localization (Draviam et al., 2001).
Cyclin B1 is primarily cytoplasmic but shuttles continuously between the nucleus and the cytoplasm during interphase (Hagting et al. 1998 Down; Toyoshima et al. 1998 Down; Yang et al. 1998 Down). At the end of prophase, it abruptly translocates into the nucleus (Furuno et al. 1999 Down; Hagting et al. 1999 Down) and then associates with mitotic apparatus (Pines and Hunter 1991 Down; Hagting et al. 1998 Down; Clute and Pines 1999 Down). Cyclin B2 is primarily associated with the Golgi apparatus during interphase and mitosis (Jackman et al. 1995 Down; Brandeis et al. 1998 Down). Cyclin B1–CDK1 promotes chromosome condensation, reorganization microtubule reorgnization, and disassembly of the nuclear lamina and the Golgi apparatus. Cyclin B2–CDK1 functions in disassembly of the Golgi apparatus (Draviam et al., 2001).

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