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Details on Person ALKBH3 (ABH3) has a preference for binding single strand DNA...
| Class:Id | Summation:179027 |
|---|---|
| _displayName | ALKBH3 (ABH3) has a preference for binding single strand DNA... |
| _timestamp | 2015-02-20 19:16:29 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5676645] Orlic-Milacic, Marija, 2015-02-20 [InstanceEdit:5676979] Orlic-Milacic, Marija, 2015-02-20 |
| text | ALKBH3 (ABH3) has a preference for binding single strand DNA or RNA containing alkylation damage. ALKBH3 associates with dsDNA containing 3-methylcytosine (3-meC-dsDNA) alkylation damage in the presence of ASCC3 DNA helicase. ASCC3 is a part of ASCC1:ASCC2:ASCC3 activating signal co-integrator complex, which unwinds dsDNA, providing an appropriate substrate for ALKBH3 (Duncan et al. 2002, Sundheim et al. 2006, Chen et al. 2010, Dango et al. 2011). ALKBH3 requires iron (Fe2+) for its catalytic activity (Duncan et al. 2002, Sundheim et al. 2006). ALKBH3 is ~2-fold more active on DNA containing 3-methylcytosine than 1-methyladenine (Duncan et al. 2002). |
| (summation) | [Reaction:5657617] ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC [Homo sapiens] |
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