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Details on Person NEXT4 fragment of NOTCH4 is further cleaved at the S3 site b...
| Class:Id | Summation:178973 |
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| _displayName | NEXT4 fragment of NOTCH4 is further cleaved at the S3 site b... |
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| _timestamp | 2018-04-06 19:20:19 |
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| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
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| literatureReference | [LiteratureReference:9604291] Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function
[LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis |
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| modified | [InstanceEdit:1367060] Orlic-Milacic, M, 2011-06-24
[InstanceEdit:1460338] Orlic-Milacic, M, 2011-07-26
[InstanceEdit:9604289] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9604700] Orlic-Milacic, Marija, 2018-04-04
[InstanceEdit:9605034] Orlic-Milacic, Marija, 2018-04-06 |
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| text | NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004). |
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| (summation) | [Reaction:9604294] Gamma-secretase cleaves NOTCH4 [Homo sapiens] |
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No pathways have been reviewed or authored by NEXT4 fragment of NOTCH4 is further cleaved at the S3 site b... (178973)
