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Details on Person NEXT1 fragment of NOTCH1 is further cleaved at S3 by the pre...
| Class:Id | Summation:178970 |
|---|---|
| _displayName | NEXT1 fragment of NOTCH1 is further cleaved at S3 by the pre... |
| _timestamp | 2012-02-28 15:08:31 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:1367060] Orlic-Milacic, M, 2011-06-24 [InstanceEdit:1460332] Orlic-Milacic, M, 2011-07-26 [InstanceEdit:2063927] Orlic-Milacic, M, 2012-01-16 [InstanceEdit:2085526] Orlic-Milacic, M, 2012-02-03 [InstanceEdit:2152408] Orlic-Milacic, M, 2012-02-27 [InstanceEdit:2157475] Orlic-Milacic, M, 2012-02-28 |
| text | NEXT1 fragment of NOTCH1 is further cleaved at S3 by the presenilin-1 (PSEN1) containing gamma-secretase complex, which releases the intracellular domain NICD1 into the cytosol (Schroeter et al. 1998, De Strooper et al. 1999, Huppert et al. 2000, Fortini et al. 2002). PIN1, a prolyl isomerase, was recently found to bind phosphorylated Ser/Thr-Pro motifs in the cytoplasmic domain of NOTCH1 and potentiate NEXT1 cleavage by gamma-secretase. This generates a positive loop in NOTCH1 signaling since PIN1 is a transcriptional target of NICD1 (Rustighi et al. 2009). |
| (summation) | [Reaction:157353] NEXT1 is cleaved to produce NICD1 [Homo sapiens] |
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No pathways have been reviewed or authored by NEXT1 fragment of NOTCH1 is further cleaved at S3 by the pre... (178970)
