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Details on Person Mitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes...

Class:IdSummation:178918
_displayNameMitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes...
_timestamp2010-02-12 15:25:52
created[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
modified[InstanceEdit:508464] D'Eustachio, P, 2010-02-12
textMitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes the reaction of isobutyryl-CoA and FAD to form methacrylyl-CoA and FADH2 (Roe et al. 1999; Nguyen et al. 2002). Crystallographic studies have shown the active enzyme to be a tetramer of ACAD8 polypeptides whose aminoterminal 23 residues, a mitochondrial targeting sequence, have been removed (Bataille et al. 2004).
(summation)[Reaction:70859] isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 [Homo sapiens]
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