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Details on Person Cytosolic xanthine dehydrogenase (XDH) in its oxidase form c...

Class:IdSummation:178880
_displayNameCytosolic xanthine dehydrogenase (XDH) in its oxidase form c...
_timestamp2021-04-15 20:27:32
created[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
modified[InstanceEdit:500141] D'Eustachio, P, 2010-01-31
[InstanceEdit:9727339] D'Eustachio, Peter, 2021-04-15
textCytosolic xanthine dehydrogenase (XDH) in its oxidase form catalyzes the reaction of hypoxanthine with H2O and oxygen to form xanthine and H2O2. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007). The enzyme is said to occur predominantly in its dehydrogenase form, catalyzing the reaction of hypoxanthine with NAD+ to form xanthine and to be converted to the oxidase form annotated here in response to stress (Ichida et al. 2012).
(summation)[Reaction:74247] XDH oxidizes hypoxanthine to form xanthine [Homo sapiens]
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