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Details on Person Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes th...
| Class:Id | Summation:178809 |
|---|---|
| _displayName | Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes th... |
| _timestamp | 2024-10-25 22:00:49 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:507953] D'Eustachio, P, 2010-02-09 [InstanceEdit:517497] D'Eustachio, P, 2010-02-18 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 |
| text | Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes the reversible reaction of glutamate and NAD(P)+ to form 2-oxoglutarate, NAD(P)H + H+, and ammonia (Fang et al. 2002). Mature GLUD1 protein lacks the 53 aminoterminal residues of the nascent protein (Julliard and Smith 1979), which function as a mitochondrial import signal. The active form of the enzyme is a hexamer, allosterically activated by ADP and inhibited by GTP (Fang et al. 2002; Smith et al. 2002). GLUD2 is inferred to catalyze the same reaction based on its structural similarity to GLUD1. |
| (summation) | [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [Homo sapiens] |
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