Query author contributions in Reactome
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Details on Person After incorporating two dAMPs opposite the thymine-thymine c...
| Class:Id | Summation:178698 |
|---|---|
| _displayName | After incorporating two dAMPs opposite the thymine-thymine c... |
| _timestamp | 2014-12-11 16:52:45 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5654982] Orlic-Milacic, Marija, 2014-12-04 [InstanceEdit:5656193] Orlic-Milacic, Marija, 2014-12-11 |
| text | After incorporating two dAMPs opposite the thymine-thymine cyclobutane pyrimidine dimer (TT-CPD), DNA polymerase eta (POLH) can continue translesion DNA synthesis (TLS). POLH preferentially incorporates dAMPs and dGMPs, and may introduce one error per every 18-380 nucleotides (dNMPs) added. POLH stalls after incorporation of a mispaired dNMP, which limits POLH- mediated mutagenesis, in addition to the subsequent polymerase switch (Matsuda et al. 2000, Masutani et al. 2000). |
| (summation) | [Reaction:110319] Elongation by POLH [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by After incorporating two dAMPs opposite the thymine-thymine c... (178698)
