Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
| Class:Id | Summation:178682 |
|---|---|
| _displayName | APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site ly... |
| _timestamp | 2014-12-19 19:59:14 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5637616] Orlic-Milacic, Marija, 2014-11-11 [InstanceEdit:5658615] Orlic-Milacic, Marija, 2014-12-19 |
| text | APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces TDG from the AP site created by the DNA glycosylase activity of TDG. In the absence of APEX1, TDG remains tightly bound to the AP site, which inhibits subsequent steps in the base excision repair. Sumoylation of TDG may also be involved in the APEX1-mediated displacement of TDG from AP sites (Hardeland et al. 2002, Steinacher and Schar 2005, Fitzgerald and Drohat 2008). |
| (summation) | [Reaction:110350] Displacement of TDG glycosylase by APEX1 at the AP site [Homo sapiens] |
| [Change default viewing format] | |