Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person At the beginning of this reaction, 1 molecule of 'phospho-SH...

Class:IdSummation:178643
_displayNameAt the beginning of this reaction, 1 molecule of 'phospho-SH...
_timestamp2017-04-06 15:46:16
created[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
literatureReference[LiteratureReference:8984407] Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
[LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner
[LiteratureReference:8984387] Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
modified[InstanceEdit:8984457] Duenas, Corina, 2017-04-06
textAt the beginning of this reaction, 1 molecule of 'phospho-SHC' is present. At the end of this reaction, 1 molecule of 'Orthophosphate', and 1 molecule of 'SHC transforming protein' are present.

This reaction takes place in the 'cytosol' and is mediated by the 'protein tyrosine phosphatase activity' of 'protein tyrosine phosphatase' (Sasaoka et al. 1996).
This is a black box event since the event of dephosphorylation is inferred from other reaction where this process occurs after other stimulation (Gu et al. 1999).
(summation)[BlackBoxEvent:74748] De-phosphorylation of p-Y427-SHC1 [Homo sapiens]
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No pathways have been reviewed or authored by At the beginning of this reaction, 1 molecule of 'phospho-SH... (178643)