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Details on Person UNG, a DNA uracil glycosylase, excises the uracil base gener...
| Class:Id | Summation:178555 |
|---|---|
| _displayName | UNG, a DNA uracil glycosylase, excises the uracil base gener... |
| _timestamp | 2014-12-19 18:02:02 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5635916] Orlic-Milacic, Marija, 2014-11-07 [InstanceEdit:5635922] Orlic-Milacic, Marija, 2014-11-07 [InstanceEdit:5635923] Orlic-Milacic, Marija, 2014-11-07 [InstanceEdit:5658591] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5658593] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5658604] Orlic-Milacic, Marija, 2014-12-19 |
| text | UNG, a DNA uracil glycosylase, excises the uracil base generated when a DNA damaging agent deaminates cytosine (creating a U:G base pair) or when dUMP is misincorporated during DNA synthesis (creating a U:A base pair). UNG scans the DNA for damage by kinking and compressing the DNA phosphate backbone with a serine-proline pinch, which causes uracil to flip out at the phosphate-sugar junction into the recognition pocket of the UNG. The subsequent excision of uracil creates an apurinic/apyrimidinic (AP) site in the DNA (Parikh et al. 1998). |
| (summation) | [Reaction:110215] Cleavage of uracil by UNG glycosylase [Homo sapiens] |
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No pathways have been reviewed or authored by UNG, a DNA uracil glycosylase, excises the uracil base gener... (178555)
