Query author contributions in Reactome
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Details on Person MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves thy...
| Class:Id | Summation:178537 |
|---|---|
| _displayName | MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves thy... |
| _timestamp | 2014-12-19 19:30:13 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5637549] Orlic-Milacic, Marija, 2014-11-10 [InstanceEdit:5651910] Orlic-Milacic, Marija, 2014-11-25 [InstanceEdit:5658607] Orlic-Milacic, Marija, 2014-12-19 |
| text | MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves thymine mispaired with guanine at CpG islands, which is a consequence of the oxidative deamination of 5-methylcytosine (Petronzelli et al. 2000). The MBD4 catalytic site is located at the C-terminus (Wu et al. 2003). MBD4 may be involved in the maintenance of genomic stability and active DNA demethylation. |
| (summation) | [Reaction:110232] Cleavage of thymine by MBD4 glycosylase [Homo sapiens] |
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No pathways have been reviewed or authored by MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves thy... (178537)
