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Details on Person Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) ca...
| Class:Id | Summation:178504 |
|---|---|
| _displayName | Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) ca... |
| _timestamp | 2010-02-12 15:25:52 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:508464] D'Eustachio, P, 2010-02-12 |
| text | Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of beta-hydroxyisobutyrate and NAD+ to form methylmalonyl semialdehyde and NADH + H+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed. |
| (summation) | [Reaction:70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Homo sapiens] |
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No pathways have been reviewed or authored by Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) ca... (178504)
