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Details on Person Cytosolic dihydroxyacetone kinase (DAK) catalyzes the reacti...
| Class:Id | Summation:178500 |
|---|---|
| _displayName | Cytosolic dihydroxyacetone kinase (DAK) catalyzes the reacti... |
| _timestamp | 2015-08-27 22:35:26 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:469706] D'Eustachio, P, 2010-01-25 [InstanceEdit:5652053] D'Eustachio, Peter, 2014-11-26 [InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:6792826] D'Eustachio, Peter, 2015-08-27 |
| text | Cytosolic dihydroxyacetone kinase (DAK) catalyzes the reaction of ATP and D-glyceraldehyde (GA) to form ADP and D-glyceraldehyde 3-phosphate (GA3P). This reaction was originally characterized in studies of guinea pig liver and human erythrocytes (Hers & Kusaka 1953; Beutler & Guinto 1973). The human enzyme has been cloned and studied (Cabezas et al. 2005; Rodrigues et al. 2014). DAK/TKFC also catalyzes the phosphorylation of dihydroxyacetone (DHA) to dihydroxyacetone phosphate (DHAP), not a necessary step in fructose catabolism, but possibly functional on exogenous DHA. Triokinase activities on GA and DHA require homodimeric enzyme formed by two-domain subunits, where triose binds to one subunit and ATP to the other, each in a different domain. DAK/TKFC is a bifunctional enzyme which, besides the ATP/Mg-dependent phosphorylation of GA and DHA, also catalyses, in presence of Mn2+, a unisubstrate reaction splitting flavin-adenine dinucleotide (FAD) into riboflavin cyclic 4',5'-phosphate (cyclic FMN) and AMP (Cabezas et al. 2005; Rodrigues et al. 2014). In addition, DAK/TKFC protein binds to MDA5 and acts as a negative regulator of MDA5-mediated induction of IFN-alpha/beta pathways (Diao et al. 2007). Potentially related to this TKFC effect are the observations that hepatic DAK/TKFC levels correlate with outcome in chronic hepatitis C patients treated with interferon (Perdomo et al. 2012), and that a DAK/TKFC serum peptide is a predictor of disease severity in hepatitis B patients (Xu et al. 2013). |
| (summation) | [Reaction:70349] DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate [Homo sapiens] |
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No pathways have been reviewed or authored by Cytosolic dihydroxyacetone kinase (DAK) catalyzes the reacti... (178500)
