Query author contributions in Reactome
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Details on Person APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site DN...
| Class:Id | Summation:178472 |
|---|---|
| _displayName | APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site DN... |
| _timestamp | 2014-12-19 20:13:33 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:5637649] Orlic-Milacic, Marija, 2014-11-11 [InstanceEdit:5649551] Orlic-Milacic, Marija, 2014-11-20 [InstanceEdit:5658618] Orlic-Milacic, Marija, 2014-12-19 |
| text | APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site DNA lyase, cleaves the DNA strand sugar-phosphate backbone 5' to the AP site generated by DNA glycosylases or that forms by spontaneous loss of a base, producing a DNA strand with a 3'-terminal unsaturated sugar and a DNA strand with a terminal abasic 5'-deoxyribosephosphate (5'-dRP) as cleavage products (Wilson et al. 1995, Bennett et al. 1997, Masuda et al. 1998, Parikh et al. 1998). |
| (summation) | [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site [Homo sapiens] |
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No pathways have been reviewed or authored by APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site DN... (178472)
