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Details on Person p115-RhoGEF is a potent GTPase activating protein (GAP) for ...
| Class:Id | Summation:178380 |
|---|---|
| _displayName | p115-RhoGEF is a potent GTPase activating protein (GAP) for ... |
| _timestamp | 2016-05-23 13:24:00 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| literatureReference | [LiteratureReference:398175] Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells |
| modified | [InstanceEdit:398180] Jupe, S, 2009-03-18 10:28:11 [InstanceEdit:419689] Jupe, S, 2009-05-05 16:57:17 [InstanceEdit:8874417] Jupe, Steve, 2016-05-23 |
| text | p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may be important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (Wang et al. 2004). |
| (summation) | [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) [Homo sapiens] |
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No pathways have been reviewed or authored by p115-RhoGEF is a potent GTPase activating protein (GAP) for ... (178380)
