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Details on Person Mitochondrial succinyl-CoA:3-ketoacid coenzyme A transferase...
| Class:Id | Summation:178368 |
|---|---|
| _displayName | Mitochondrial succinyl-CoA:3-ketoacid coenzyme A transferase... |
| _timestamp | 2017-01-12 13:34:35 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:1433615] D'Eustachio, P, 2011-07-11 [InstanceEdit:8955626] Jassal, Bijay, 2017-01-12 [InstanceEdit:8955633] Jassal, Bijay, 2017-01-12 [InstanceEdit:8955638] Jassal, Bijay, 2017-01-12 [InstanceEdit:8955639] Jassal, Bijay, 2017-01-12 |
| text | Mitochondrial succinyl-CoA:3-ketoacid coenzyme A transferases 1 and 2 (OXCT1 and OXCT2) are key enzymes for the metabolism of ketone bodies, catalysing the first rate-limiting step of ketone body utilisation in peripheral tissues. In dimeric form, they mediate the transfer of a CoA moiety from succinyl-CoA (SUCC-CoA) to acetoacetate (ACA) to form acetoacetyl-CoA (ACA-CoA) and succinate (SUCCA) (Kassovska-Bratinova et al. 1996, Tanaka et al. 2002). ACA-CoA can be converted to acetyl-CoA which can be utilised by the tricarboxylic acid cycle for energy production. |
| (summation) | [Reaction:74177] OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA [Homo sapiens] |
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No pathways have been reviewed or authored by Mitochondrial succinyl-CoA:3-ketoacid coenzyme A transferase... (178368)
