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Details on Person N-acetyl-p-benzoquinone imine (NAPQI) is the reactive interm...

Class:IdSummation:178367
_displayNameN-acetyl-p-benzoquinone imine (NAPQI) is the reactive interm...
_timestamp2008-02-08 15:23:35
created[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
modified[InstanceEdit:211789] Jassal, Bijay, 2008-02-08
textN-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.
(summation)[Reaction:76397] Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) [Homo sapiens]
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