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Details on Person Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro...
| Class:Id | Summation:178300 |
|---|---|
| _displayName | Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro... |
| _timestamp | 2013-03-18 14:52:10 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:500111] D'Eustachio, P, 2010-01-31 [InstanceEdit:3222067] D'Eustachio, P, 2013-03-18 |
| text | Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydrolysis of GMP, dGMP, IMP, and dIMP to yield the corresponding nucleosides and orthophosphate (Bianchi and Spychala 2003; Spychala et al. 1988). The active form of the enzyme is a tetramer and has an absolute requirement for magnesium ions (Spychala et al. 1988; Wallden et al. 2007). Consistent with the biochemical properties of purified enzyme, cultured cells overexpressing the enzyme from a recombinant DNA clone showed enhanced activity against inosine and guanosine monophosphates, but not adenosine monophosphate (Gazziola et al. 2001; Sala-Newby et al. 2000). |
| (summation) | [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Homo sapiens] |
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No pathways have been reviewed or authored by Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro... (178300)
