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Details on Person Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions...
| Class:Id | Summation:178274 |
|---|---|
| _displayName | Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions... |
| _timestamp | 2010-02-05 17:04:26 |
| created | [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48 |
| modified | [InstanceEdit:500827] D'Eustachio, P, 2010-02-05 |
| text | Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions of cytidine or deoxycytidine with ATP to form CMP or dCMP and ADP. The enzyme is a homodimer (Sabini et al. 2003). Although a chimeric deoxycytidine kinase - green fluorescent protein expressed at high levels in cultured cells localized to nuclei, endogenous protein is primarily cytosolic (Hatzis et al. 1998). Despite its name, the enzyme has a broad substrate specificity, acting on cytidine, deoxycytidine, deoxyguanosine, and deoxyadenosine (Bohman and Eriksson 1988; Datta et al. 1989a, b; Sarup et al. 1989; Usova and Eriksson 2002). While ATP functions efficiently as a phosphate donor, other nucleoside triphosphates, notably UTP, function efficiently as phosphate donors in vitro and may function in this way in vivo as well (Shewach et al. 1992). |
| (summation) | [Reaction:73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) [Homo sapiens] |
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