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Query author contributions in Reactome

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Details on Person SMAD7 binds to SMURF2

Class:IdReaction:178208
_displayNameSMAD7 binds to SMURF2
_doReleaseTRUE
_timestamp2012-05-31 09:46:54
authored[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:178182] Jassal, B, 2006-04-18 14:28:42
edited[InstanceEdit:2187413] Jassal, B, 2012-04-10
input[EntityWithAccessionedSequence:178197] SMAD7 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:178202] SMURF2 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:178228] Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
[LiteratureReference:178212] Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain
modified[InstanceEdit:2167891] Orlic-Milacic, M, 2012-03-22
[InstanceEdit:2168999] Orlic-Milacic, M, 2012-03-26
[InstanceEdit:2187532] Orlic-Milacic, M, 2012-04-10
[InstanceEdit:2197658] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2197822] Orlic-Milacic, M, 2012-04-16
[InstanceEdit:2250347] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSMAD7 binds to SMURF2
output[Complex:2167870] SMAD7:SMURF2 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2295024] R-HSA-178208.2
summation[Summation:2167875] SMURF2, an E3 ubiquitin protein ligase, binds to SMAD7 in th...
(hasEvent)[Pathway:177106] I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation [Homo sapiens]
[Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)[Reaction:2167876] SMAD7:SMURF2 complex translocates to the cytosol [Homo sapiens]
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