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Details on Person SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR

Class:Id	Reaction:178189
_displayName	SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
_doRelease	TRUE
_timestamp	2013-01-11 14:10:14
authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment	[Compartment:70101] cytosol [Compartment:171062] early endosome membrane [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:178182] Jassal, B, 2006-04-18 14:28:42
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10
inferredFrom	[Reaction:2167890] Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex [Homo sapiens]
input	[Complex:173476] TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] [Homo sapiens] [Complex:2162158] GADD34:PP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:206180] ZFYVE9-1 [early endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:178179] GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor
modified	[InstanceEdit:2167891] Orlic-Milacic, M, 2012-03-22 [InstanceEdit:2187532] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197658] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2197822] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2199156] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2250348] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:2980621] Jassal, B, 2013-01-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
output	[Complex:2167884] TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) [Homo sapiens] [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295111] R-HSA-178189.2
summation	[Summation:2167889] SMAD7 recruits protein phosphatase 1 (PP1) to TGF-beta recep...
(hasEvent)	[Pathway:177106] I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation [Homo sapiens] [Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:178166] I-SMAD:GADD34 binds to type I receptor [Homo sapiens] [Reaction:178178] PP1 dephosphorylates TGFBR1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787001] Update Tracker - [Reaction:178189] SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR - v46:[modifyText] [_UpdateTracker:9787892] Update Tracker - [Reaction:178189] SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR - v44:[add_removeInput]
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