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Details on Person I-SMAD:GADD34 binds to type I receptor

Class:Id	Reaction:178166
_displayName	I-SMAD:GADD34 binds to type I receptor
_doRelease	FALSE
_timestamp	2016-12-01 00:31:44
authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:178182] Jassal, B, 2006-04-18 14:28:42
input	[Complex:178163] I-SMAD:GADD34-PP1c [cytosol] [Homo sapiens] [Complex:170863] p-TGFBR1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:178179] GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01
name	I-SMAD:GADD34 binds to type I receptor
output	[Complex:178171] I-SMAD:GADD34-PP1c:Phospho-type I receptor [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:178189] SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR [Homo sapiens] [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) [Homo sapiens]
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8881055] R-HSA-178166.1
(hasEvent)	[Pathway:177106] I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation [Homo sapiens]
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No pathways have been reviewed or authored by I-SMAD:GADD34 binds to type I receptor (178166)