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Details on Person Pro-EGF is cleaved to form mature EGF

Class:Id	Reaction:177946
_displayName	Pro-EGF is cleaved to form mature EGF
_doRelease	TRUE
_timestamp	2008-06-20 09:44:02
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:179871] metalloendopeptidase activity of ADAM:Zn2+ [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
inferredFrom	[Reaction:179883] Mouse pro-EGF is cleaved by ADAM sheddases [Mus musculus]
input	[EntityWithAccessionedSequence:179888] Pro-EGF [plasma membrane] [Homo sapiens]
modified	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09 [InstanceEdit:188419] Jassal, Bijay, 2006-10-12 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Pro-EGF is cleaved to form mature EGF
output	[EntityWithAccessionedSequence:179863] EGF [extracellular region] [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:193358] Muthuswamy, S, 2007-02-16 20:08:05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361451] R-HSA-177946.2
summation	[Summation:179818] Ligands of the epidermal growth factor receptor (EGFR) are ...
(hasEvent)	[Pathway:177929] Signaling by EGFR [Homo sapiens]
(precedingEvent)	[Reaction:177942] EGFR binds EGF ligand [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792081] Update Tracker - [Reaction:177946] Pro-EGF is cleaved to form mature EGF - v24:[modifyText]
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No pathways have been reviewed or authored by Pro-EGF is cleaved to form mature EGF (177946)