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Details on Person SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)

Class:Id	Reaction:177945
_displayName	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
_doRelease	TRUE
_timestamp	2011-09-07 19:13:26
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:180290] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure	[Figure:179426] /figures/sos_acts_ras.jpg
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:179435] Jassal, Bijay, 2006-04-28 [InstanceEdit:180351] Jassal, B, 2006-05-18 13:22:07 [InstanceEdit:188420] Jassal, B, 2006-10-12 13:44:51 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06 [InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens] [Reaction:177933] SHC1 phosphorylation by phosphorylated EGFR [Homo sapiens] [Reaction:109813] GRB2-1 binds SOS1 [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360582] R-HSA-177945.2
summation	[Summation:188533] Son of sevenless homolog 1 (SOS1) is the guanine nucleotide ...
(hasEvent)	[Pathway:180336] SHC1 events in EGFR signaling [Homo sapiens]
(normalReaction)	[Reaction:1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) [Homo sapiens] [Reaction:5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778566] Update Tracker - [Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - v68:[modifyText] [_UpdateTracker:9789169] Update Tracker - [Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - v38:[modifyText]
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No pathways have been reviewed or authored by SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (177945)