Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Activation of SHP2 through the binding to phospho-Gab1

Class:Id	Reaction:177944
_displayName	Activation of SHP2 through the binding to phospho-Gab1
_doRelease	TRUE
_timestamp	2008-06-20 09:44:59
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
figure	[Figure:179428] /figures/phosGAB_SHP2.jpg
input	[Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:180288] Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells [LiteratureReference:180316] Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
modified	[InstanceEdit:179435] Jassal, Bijay, 2006-04-28 [InstanceEdit:180350] Jassal, B, 2006-05-18 13:20:28 [InstanceEdit:188407] Jassal, B, 2006-10-12 13:35:44 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188436] Jassal, B, 2006-10-13 13:48:32 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212478] Jassal, B, 2008-02-12 10:47:05 [InstanceEdit:213071] Jassal, B, 2008-02-20 10:10:54 [InstanceEdit:213074] Jassal, B, 2008-02-20 10:13:39 [InstanceEdit:213442] Jassal, Bijay, 2008-02-26 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of SHP2 through the binding to phospho-Gab1
output	[Complex:180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177930] GAB1 phosphorylation by EGFR kinase [Homo sapiens] [Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362074] R-HSA-177944.2
summation	[Summation:180311] The SH2 domains repress phosphatase activity of SHP2. Bindin...
(hasEvent)	[Pathway:180292] GAB1 signalosome [Homo sapiens]
(precedingEvent)	[Reaction:177923] Sustained activation of SRC kinase by SHP2 [Homo sapiens] [Reaction:177924] Dephosphorylation of Gab1 by SHP2 [Homo sapiens] [Reaction:177926] Dephosphorylation of PAG by SHP2 [Homo sapiens] [Reaction:177935] SHP2 dephosphorylates Tyr 992 on EGFR [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Activation of SHP2 through the binding to phospho-Gab1 (177944)