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Details on Person GRB2:SOS1 complex binds to EGF:EGFR complex

Class:IdReaction:177943
_displayNameGRB2:SOS1 complex binds to EGF:EGFR complex
_doReleaseTRUE
_timestamp2024-03-19 12:24:49
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure[Figure:179463] /figures/sos_gbr2_binds_egfr_egf.jpg
input[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
[Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:179801] Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells
[LiteratureReference:179887] Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
modified[InstanceEdit:179464] Jassal, B, 2006-05-02 12:42:49
[InstanceEdit:179468] Jassal, B, 2006-05-03 10:36:01
[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
[InstanceEdit:188420] Jassal, B, 2006-10-12 13:44:51
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188444] Jassal, Bijay, 2006-10-13
[InstanceEdit:188569] Jassal, Bijay, 2006-10-18
[InstanceEdit:188582] Jassal, Bijay, 2006-10-18
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1566988] Orlic-Milacic, Marija, 2011-09-06
[InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07
[InstanceEdit:2018636] Jassal, Bijay, 2011-11-23
[InstanceEdit:9624468] Rothfels, Karen, 2018-10-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
nameGRB2:SOS1 complex binds to EGF:EGFR complex
negativePrecedingEvent[NegativePrecedingEvent:9865815] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
output[Complex:179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358620] R-HSA-177943.4
summation[Summation:188438] Cytoplasmic target proteins containing the SH2 domain can bi...
(hasEvent)[Pathway:179812] GRB2 events in EGFR signaling [Homo sapiens]
(normalReaction)[Reaction:1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants [Homo sapiens]
[Reaction:5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII [Homo sapiens]
(precedingEvent)[Reaction:177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Homo sapiens]
[Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778967] Update Tracker - [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex - v67:[add_removeInput]
[_UpdateTracker:9846639] Update Tracker - [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex - v84:[modifyText]
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