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Details on Person EGFR binds EGF ligand

Class:Id	Reaction:177942
_displayName	EGFR binds EGF ligand
_doRelease	TRUE
_timestamp	2018-10-11 15:14:24
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
input	[EntityWithAccessionedSequence:179837] EGFR [plasma membrane] [Homo sapiens] [DefinedSet:9624194] EGF-like ligands [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:188642] Activation of epidermal growth factor receptor by epidermal growth factor
modified	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09 [InstanceEdit:188417] Jassal, Bijay, 2006-10-12 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188444] Jassal, Bijay, 2006-10-13 [InstanceEdit:188641] Jassal, Bijay, 2006-10-19 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9624465] Rothfels, Karen, 2018-10-11 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGFR binds EGF ligand
output	[Complex:9624419] EGFR:EGF-like ligands [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177946] Pro-EGF is cleaved to form mature EGF [Homo sapiens]
regulatedBy	[NegativeRegulation:204695] Negative regulation by 'LRIG1 [plasma membrane]'
regulationReference	[RegulationReference:9642127] Negative regulation by 'LRIG1 [plasma membrane]' A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity
releaseDate	2007-02-20
reviewed	[InstanceEdit:193358] Muthuswamy, S, 2007-02-16 20:08:05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359702] R-HSA-177942.5
summation	[Summation:188443] The prototypic receptor tyrosine kinase (RTK) EGFR is compos...
(hasEvent)	[Pathway:177929] Signaling by EGFR [Homo sapiens]
(normalReaction)	[Reaction:1220612] Binding of EGF to ligand-responsive EGFR mutants [Homo sapiens] [FailedReaction:5638137] EGFRvIII cancer variant does not bind EGF ligand [Homo sapiens]
(precedingEvent)	[Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1977959] ERBB4 forms heterodimers with EGFR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778883] Update Tracker - [Reaction:177942] EGFR binds EGF ligand - v67:[add_removeInput, add_removeOutput] [_UpdateTracker:9792164] Update Tracker - [Reaction:177942] EGFR binds EGF ligand - v23:[addRegulator]
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No pathways have been reviewed or authored by EGFR binds EGF ligand (177942)