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Details on Person GRB2:GAB1 binds to phosphorylated EGFR

Class:Id	Reaction:177941
_displayName	GRB2:GAB1 binds to phosphorylated EGFR
_doRelease	TRUE
_timestamp	2024-03-19 12:24:46
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
input	[DefinedSet:9038397] GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] [Homo sapiens] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:188537] Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
modified	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09 [InstanceEdit:180350] Jassal, B, 2006-05-18 13:20:28 [InstanceEdit:188418] Jassal, B, 2006-10-12 13:41:50 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06 [InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:9031667] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9031710] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9031712] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9038402] Orlic-Milacic, Marija, 2018-02-26 [InstanceEdit:9624467] Rothfels, Karen, 2018-10-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
name	GRB2:GAB1 binds to phosphorylated EGFR
negativePrecedingEvent	[NegativePrecedingEvent:9865814] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
output	[Complex:180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177934] EGFR autophosphorylation [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:9851407] FAM83B, (FAM83A, FAM83D) bind EGFR [Homo sapiens] [Reaction:177920] Binding of GRB2 to GAB1 [Homo sapiens] [Reaction:179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] [Reaction:177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Homo sapiens] [Reaction:177920] Binding of GRB2 to GAB1 [Homo sapiens] [Reaction:177937] Phosphorylation of EGFR by SRC kinase [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360359] R-HSA-177941.5
summation	[Summation:188534] The regulatory subunit of PIK3 mediates the association of G...
(hasEvent)	[Pathway:180292] GAB1 signalosome [Homo sapiens]
(normalReaction)	[Reaction:1226016] Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant [Homo sapiens]
(precedingEvent)	[Reaction:177930] GAB1 phosphorylation by EGFR kinase [Homo sapiens]
(replacementInstances)	[_Deleted:9038406] Deletion of instance: 177940
(updatedInstance)	[_UpdateTracker:9778899] Update Tracker - [Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR - v67:[add_removeInput] [_UpdateTracker:9779702] Update Tracker - [Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR - v64:[add_removeInput, add_removeOutput] [_UpdateTracker:9789461] Update Tracker - [Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR - v38:[modifyText]
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