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Details on Person PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)

Class:Id	Reaction:177939
_displayName	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
_doRelease	TRUE
_timestamp	2017-12-01 17:49:05
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:179881] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure	[Figure:179450] /figures/pi3k_converts_pip2_2_pip3.jpg
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
modified	[InstanceEdit:179435] Jassal, Bijay, 2006-04-28 [InstanceEdit:179451] Jassal, B, 2006-05-02 10:20:12 [InstanceEdit:179808] Jassal, Bijay, 2006-05-09 [InstanceEdit:188419] Jassal, Bijay, 2006-10-12 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212462] Jassal, B, 2008-02-11 14:13:21 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06 [InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:9031710] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens] [Reaction:177930] GAB1 phosphorylation by EGFR kinase [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359174] R-HSA-177939.3
summation	[Summation:188531] The kinase activity of PIK3 mediates the phosphorylation of ...
(hasEvent)	[Pathway:180292] GAB1 signalosome [Homo sapiens]
(normalReaction)	[Reaction:1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII [Homo sapiens]
(precedingEvent)	[Reaction:179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] [Reaction:9846380] GOCAM GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789297] Update Tracker - [Reaction:177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - v38:[modifyText]
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No pathways have been reviewed or authored by PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (177939)