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Details on Person Phosphorylation of EGFR by SRC kinase

Class:IdReaction:177937
_displayNamePhosphorylation of EGFR by SRC kinase
_doReleaseTRUE
_timestamp2024-03-19 12:24:59
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity[CatalystActivity:179862] protein tyrosine kinase activity of SRC-1 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure[Figure:189925] /figures/egfr_P_by_src.jpg
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:9624420] EGF-like ligands:EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:179802] In vitro phosphorylation of the epidermal growth factor receptor autophosphorylation domain by c-src: identification of phosphorylation sites and c-src SH2 domain binding sites
modified[InstanceEdit:179435] Jassal, Bijay, 2006-04-28
[InstanceEdit:179446] Jassal, Bijay, 2006-05-02
[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
[InstanceEdit:188419] Jassal, Bijay, 2006-10-12
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188444] Jassal, Bijay, 2006-10-13
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:189924] Jassal, Bijay, 2006-12-08
[InstanceEdit:189934] Jassal, Bijay, 2006-12-08
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1483054] Orlic-Milacic, Marija, 2011-08-12
[InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07
[InstanceEdit:2018637] Jassal, Bijay, 2011-11-23
[InstanceEdit:9624473] Rothfels, Karen, 2018-10-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
namePhosphorylation of EGFR by SRC kinase
negativePrecedingEvent[NegativePrecedingEvent:9865816] Futile Cycle: PTPRK dephosphorylates p-6Y-EGFR
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2007-02-20
reviewed[InstanceEdit:193358] Muthuswamy, S, 2007-02-16 20:08:05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360465] R-HSA-177937.4
summation[Summation:188445] Besides autophosphorylation, EGFR can become tyrosine-phosph...
(hasEvent)[Pathway:177929] Signaling by EGFR [Homo sapiens]
(precedingEvent)[Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex [Homo sapiens]
[Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR [Homo sapiens]
[Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens]
[Reaction:183055] Binding of CBL to EGFR [Homo sapiens]
[Reaction:183067] Localization of CBL:GRB2 to the membrane [Homo sapiens]
[Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor [Homo sapiens]
[Reaction:6785705] PTPRK dephosphorylates p-6Y-EGFR [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778783] Update Tracker - [Reaction:177937] Phosphorylation of EGFR by SRC kinase - v67:[add_removeInput, add_removeOutput]
[_UpdateTracker:9789228] Update Tracker - [Reaction:177937] Phosphorylation of EGFR by SRC kinase - v38:[modifyText]
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No pathways have been reviewed or authored by Phosphorylation of EGFR by SRC kinase (177937)
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