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Details on Person SHP2 dephosphorylates Tyr 992 on EGFR

Class:Id	Reaction:177935
_displayName	SHP2 dephosphorylates Tyr 992 on EGFR
_doRelease	TRUE
_timestamp	2008-06-20 09:43:37
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:180501] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
input	[Complex:180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:180330] Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
modified	[InstanceEdit:180351] Jassal, B, 2006-05-18 13:22:07 [InstanceEdit:180525] Jassal, B, 2006-05-23 09:32:49 [InstanceEdit:188420] Jassal, B, 2006-10-12 13:44:51 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188582] Jassal, Bijay, 2006-10-18 [InstanceEdit:188946] Gopinathrao, G, 2006-10-31 10:22:09 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:213074] Jassal, B, 2008-02-20 10:13:39 [InstanceEdit:213442] Jassal, Bijay, 2008-02-26 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHP2 dephosphorylates Tyr 992 on EGFR
output	[Complex:180326] EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:177944] Activation of SHP2 through the binding to phospho-Gab1 [Homo sapiens] [Reaction:177930] GAB1 phosphorylation by EGFR kinase [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361179] R-HSA-177935.2
summation	[Summation:188581] The tyrosine-protein phosphatase SHP2 is a positive effector...
(hasEvent)	[Pathway:180292] GAB1 signalosome [Homo sapiens]
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No pathways have been reviewed or authored by SHP2 dephosphorylates Tyr 992 on EGFR (177935)