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Details on Person SHC1 phosphorylation by phosphorylated EGFR

Class:IdReaction:177933
_displayNameSHC1 phosphorylation by phosphorylated EGFR
_doReleaseTRUE
_timestamp2018-10-11 15:14:40
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity[CatalystActivity:9624433] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure[Figure:179445] /figures/egfr_phos_of_shc_.jpg
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:180308] Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites
[LiteratureReference:180313] Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2
modified[InstanceEdit:179435] Jassal, Bijay, 2006-04-28
[InstanceEdit:179446] Jassal, Bijay, 2006-05-02
[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
[InstanceEdit:180351] Jassal, B, 2006-05-18 13:22:07
[InstanceEdit:188419] Jassal, Bijay, 2006-10-12
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06
[InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07
[InstanceEdit:9624477] Rothfels, Karen, 2018-10-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSHC1 phosphorylation by phosphorylated EGFR
output[Complex:180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360605] R-HSA-177933.3
summation[Summation:188540] Once bound to EGFR, SHC1 is phosphorylated on two tyrosines ...
(hasEvent)[Pathway:180336] SHC1 events in EGFR signaling [Homo sapiens]
(normalReaction)[Reaction:1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants [Homo sapiens]
[Reaction:5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII [Homo sapiens]
(precedingEvent)[Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778940] Update Tracker - [Reaction:177933] SHC1 phosphorylation by phosphorylated EGFR - v67:[add_removeCatalystActivity, add_removeInput]
[_UpdateTracker:9789323] Update Tracker - [Reaction:177933] SHC1 phosphorylation by phosphorylated EGFR - v38:[modifyText]
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No pathways have been reviewed or authored by SHC1 phosphorylation by phosphorylated EGFR (177933)
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