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Details on Person GAB1 phosphorylation by EGFR kinase

Class:Id	Reaction:177930
_displayName	GAB1 phosphorylation by EGFR kinase
_doRelease	TRUE
_timestamp	2017-12-01 17:49:05
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:180302] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
input	[Complex:180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:180279] Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro [LiteratureReference:180324] Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites
modified	[InstanceEdit:180350] Jassal, B, 2006-05-18 13:20:28 [InstanceEdit:180508] Jassal, B, 2006-05-23 09:31:46 [InstanceEdit:188418] Jassal, B, 2006-10-12 13:41:50 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188574] Jassal, B, 2006-10-18 09:56:53 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:9031710] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GAB1 phosphorylation by EGFR kinase
output	[Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR [Homo sapiens] [Reaction:177934] EGFR autophosphorylation [Homo sapiens] [Reaction:177920] Binding of GRB2 to GAB1 [Homo sapiens] [Reaction:179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] [Reaction:177937] Phosphorylation of EGFR by SRC kinase [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359967] R-HSA-177930.3
summation	[Summation:188578] EGFR kinase phosphorylates the phosphorylation sites tyrosin...
(hasEvent)	[Pathway:180292] GAB1 signalosome [Homo sapiens]
(precedingEvent)	[Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens] [Reaction:177944] Activation of SHP2 through the binding to phospho-Gab1 [Homo sapiens]
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No pathways have been reviewed or authored by GAB1 phosphorylation by EGFR kinase (177930)