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Details on Person PI3K binds to EGF:EGFR:GRB2:GAB1

Class:IdReaction:177927
_displayNamePI3K binds to EGF:EGFR:GRB2:GAB1
_doReleaseTRUE
_timestamp2017-12-01 17:49:05
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
edited[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure[Figure:179452] /figures/pi3k_cat_unit_binds.jpg
input[Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [Homo sapiens]
[Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
[LiteratureReference:179884] Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein
modified[InstanceEdit:179435] Jassal, Bijay, 2006-04-28
[InstanceEdit:179453] Jassal, B, 2006-05-02 10:25:36
[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
[InstanceEdit:188419] Jassal, Bijay, 2006-10-12
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06
[InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07
[InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14
[InstanceEdit:9031667] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9031710] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePI3K binds to EGF:EGFR:GRB2:GAB1
output[Complex:179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361232] R-HSA-177927.3
summation[Summation:188530] The Src homology 2 (SH2) domain of the phosphatidylinositol ...
(hasEvent)[Pathway:180292] GAB1 signalosome [Homo sapiens]
(normalReaction)[Reaction:1226012] Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants [Homo sapiens]
[Reaction:5637765] Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII [Homo sapiens]
(precedingEvent)[Reaction:177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Homo sapiens]
[Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779988] Update Tracker - [Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - v64:[addLiteratureReference, add_removeInput, modifyText]
[_UpdateTracker:9789392] Update Tracker - [Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - v38:[modifyText]
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