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Details on Person Sustained activation of SRC kinase by SHP2

Class:IdReaction:177923
_displayNameSustained activation of SRC kinase by SHP2
_doReleaseTRUE
_timestamp2024-03-19 12:25:03
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity[CatalystActivity:180501] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
input[Complex:180522] p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] [Homo sapiens]
[SimpleEntity:29356] H2O [cytosol]
literatureReference[LiteratureReference:180518] A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
[LiteratureReference:180502] Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
modified[InstanceEdit:179468] Jassal, B, 2006-05-03 10:36:01
[InstanceEdit:180351] Jassal, B, 2006-05-18 13:22:07
[InstanceEdit:180525] Jassal, B, 2006-05-23 09:32:49
[InstanceEdit:188421] Jassal, B, 2006-10-12 13:45:55
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:213074] Jassal, B, 2008-02-20 10:13:39
[InstanceEdit:213442] Jassal, Bijay, 2008-02-26
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9031692] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
nameSustained activation of SRC kinase by SHP2
output[EntityWithAccessionedSequence:180499] CSK [plasma membrane] [Homo sapiens]
[Complex:180523] PXN:MyrG-SRC [plasma membrane] [Homo sapiens]
[SimpleEntity:29372] Pi [cytosol]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359560] R-HSA-177923.4
summation[Summation:180519] SHP2 can dephosphorylate paxillin, which leads to CSK dissoc...
(hasEvent)[Pathway:180292] GAB1 signalosome [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779933] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v64:[addLiteratureReference]
[_UpdateTracker:9853296] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v87:[modifyText]
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