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Details on Person Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6

Class:Id	Reaction:177694
_displayName	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
_doRelease	TRUE
_timestamp	2017-12-01 23:36:59
authored	[InstanceEdit:450361] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:177688] Gillespie, ME, 2006-04-04 05:49:12
edited	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
input	[EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:500568] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway [LiteratureReference:434114] TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL [LiteratureReference:208040] Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
modified	[InstanceEdit:177905] Gillespie, ME, 2006-04-11 02:47:48 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:450361] Shamovsky, V, 2009-12-16 [InstanceEdit:500566] Shamovsky, V, 2010-02-04 [InstanceEdit:525804] Shamovsky, V, 2010-02-22 [InstanceEdit:525852] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2457719] Shamovsky, V, 2012-08-28 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8979781] Shamovsky, Veronica, 2017-02-27 [InstanceEdit:9014356] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
output	[Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) [Homo sapiens] [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8899767] R-HSA-177694.3
summation	[Summation:446616] TRAF6 is recruited to the N-terminal domain of TICAM1 and th...
(hasEvent)	[Pathway:9014325] TICAM1,TRAF6-dependent induction of TAK1 complex [Homo sapiens]
(inferredFrom)	[Reaction:433808] viral dsRNA: TLR3: TICAM1 recruits TRAF6 [Gallus gallus]
(precedingEvent)	[BlackBoxEvent:450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790810] Update Tracker - [Reaction:177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 - v32:[add_removeLiteratureReference, add_removeSummation]
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