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Details on Person viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]

Class:Id	Complex:177693
_displayName	viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]
_timestamp	2017-12-01 23:52:53
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:177688] Gillespie, ME, 2006-04-04 05:49:12
hasComponent	[Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] [Homo sapiens] [Complex:167985] viral dsRNA :TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2000341] TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2000341] TLR3 [endosome membrane] [Homo sapiens] [DefinedSet:9038432] TLR3 ligand [endosome lumen] [Hepatitis B virus] [EntityWithAccessionedSequence:450316] TICAM1 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:450316] TICAM1 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:450272] TRAF6 [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:500568] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway [LiteratureReference:2428862] Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation [LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
modified	[InstanceEdit:450362] Shamovsky, V, 2009-12-16 [InstanceEdit:1564932] Shamovsky, V, 2011-09-06 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9014363] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	viral dsRNA:TLR3:TRIF:TRAF6
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8908717] R-HSA-177693.2
(input)	[BlackBoxEvent:450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex [Homo sapiens]
(output)	[Reaction:177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 [Homo sapiens]
(physicalEntity)	[CatalystActivity:450331] unknown activity of viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]
(updatedInstance)	[_UpdateTracker:9869114] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, updateContainedComponent] [_UpdateTracker:9870552] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v38:[modifyName, updateContainedComponent] [_UpdateTracker:9871070] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v39:[updateContainedComponent] [_UpdateTracker:9898182] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v63:[updateContainedComponent] [_UpdateTracker:9898969] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v64:[updateContainedComponent]
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No pathways have been reviewed or authored by viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] (177693)