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Details on Person Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex

Class:IdReaction:177690
_displayNameActivated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
_doReleaseTRUE
_timestamp2018-11-08 19:18:31
authored[InstanceEdit:450360] Shamovsky, V, 2009-12-16
compartment[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created[InstanceEdit:177688] Gillespie, ME, 2006-04-04 05:49:12
edited[InstanceEdit:450323] Shamovsky, V, 2009-12-16
input[Complex:450277] TAB1:TAB2,TAB3:TAK1 [cytosol] [Homo sapiens]
[Complex:450277] TAB1:TAB2,TAB3:TAK1 [cytosol] [Homo sapiens]
[Complex:450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] [Homo sapiens]
[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
[LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
modified[InstanceEdit:177910] Gillespie, ME, 2006-04-11 02:48:31
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:450360] Shamovsky, V, 2009-12-16
[InstanceEdit:452129] Shamovsky, V, 2010-01-15
[InstanceEdit:452140] Shamovsky, V, 2010-01-15
[InstanceEdit:500475] Shamovsky, V, 2010-02-04
[InstanceEdit:525804] Shamovsky, V, 2010-02-22
[InstanceEdit:532463] Shamovsky, V, 2010-02-27
[InstanceEdit:1986609] Shamovsky, V, 2011-11-11
[InstanceEdit:2457719] Shamovsky, V, 2012-08-28
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8979781] Shamovsky, Veronica, 2017-02-27
[InstanceEdit:9014308] Shamovsky, Veronica, 2017-07-28
[InstanceEdit:9014328] Shamovsky, Veronica, 2017-07-28
[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9628448] Shamovsky, Veronica, 2018-11-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
output[Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
releaseDate2010-12-14
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:450360] Shamovsky, V, 2009-12-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8927657] R-HSA-177690.4
summation[Summation:450280] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
(hasEvent)[Pathway:9014325] TICAM1,TRAF6-dependent induction of TAK1 complex [Homo sapiens]
(inferredFrom)[Reaction:433950] TRAF6 recruits TAK1 kinase complex [Gallus gallus]
(precedingEvent)[Reaction:177692] Activation of recruited TAK1 within the activated TLR3 complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788994] Update Tracker - [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - v39:[add_removeCatalystActivity]
[_UpdateTracker:9791134] Update Tracker - [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - v32:[addCatalystActivity, addLiteratureReference, add_removeInput, add_removeSummation]
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