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Details on Person Dimerized phospho-IRF3/IRF7 is transported to the nucleus

Class:Id	Reaction:177671
_displayName	Dimerized phospho-IRF3/IRF7 is transported to the nucleus
_doRelease	TRUE
_timestamp	2022-03-04 00:22:03
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:177664] Gillespie, ME, 2006-04-03 21:05:10
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[DefinedSet:450256] phosphorylated IRF3 and/or IRF7 dimer [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
modified	[InstanceEdit:177911] Gillespie, ME, 2006-04-11 02:48:34 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:450360] Shamovsky, V, 2009-12-16 [InstanceEdit:500513] Shamovsky, V, 2010-02-04 [InstanceEdit:525804] Shamovsky, V, 2010-02-22 [InstanceEdit:525842] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:918223] Garapati, P V, 2010-08-02 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1095194] Shamovsky, V, 2010-11-30 [InstanceEdit:1565001] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2032329] Shamovsky, V, 2012-01-06 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632485] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:9765935] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9768017] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9768139] Shamovsky, Veronica, 2022-03-04 [InstanceEdit:9768146] Shamovsky, Veronica, 2022-03-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerized phospho-IRF3/IRF7 is transported to the nucleus
output	[DefinedSet:450349] phosphorylated IRF3 and/or IRF7 dimer [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:168933] Dimerization of phosphorylated IRF3/IRF7 [Homo sapiens] [Reaction:168903] Phosphorylation and Release of IRF3 or IRF7 [Homo sapiens] [Reaction:918229] Phosphorylation and release of IRF3/IRF7 [Homo sapiens] [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex [Homo sapiens]
releaseDate	2010-12-14
requiredInputComponent	[Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Homo sapiens]
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359954] R-HSA-177671.3
summation	[Summation:178674] IRF3-P:IRF3-P' is translocated from cytosol to nucleoplasm.
(hasEvent)	[Pathway:168936] Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon [Homo sapiens] [Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens] [Pathway:9013973] TICAM1-dependent activation of IRF3/IRF7 [Homo sapiens]
(inferredFrom)	[Reaction:433967] Dimerized Phospho-IRF3 is Transported To The Nucleus [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9790049] Update Tracker - [Reaction:177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - v35:[modifyText] [_UpdateTracker:9790940] Update Tracker - [Reaction:177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - v32:[add_removeInput, add_removeOutput]
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