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Details on Person RNase H catalyzes the precise cleavage of the bonds linking ...
| Class:Id | Summation:177430 |
|---|---|
| _displayName | RNase H catalyzes the precise cleavage of the bonds linking ... |
| _timestamp | 2006-10-17 19:40:09 |
| created | [InstanceEdit:177417] D'Eustachio, P, 2006-03-30 15:26:43 |
| literatureReference | [LiteratureReference:177456] Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase [LiteratureReference:182836] 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus |
| modified | [InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19 [InstanceEdit:183136] D'Eustachio, P, 2006-07-21 15:54:07 [InstanceEdit:188333] Gopinathrao, G, 2006-10-06 22:15:12 [InstanceEdit:188558] D'Eustachio, P, 2006-10-17 19:40:04 |
| text | RNase H catalyzes the precise cleavage of the bonds linking the primer tRNA attached to the minus-strand DNA, the 3' PPT RNA primer to the plus-strand strong-stop DNA, and the cPPT primer to the stretch of plus-strand DNA whose synthesis it primed. In each case, precise cleavage near the RNA-DNA junction occurs (Pullen et al. 1992). HIV-1 RT is the only reverse transcriptase that cleaves the tRNA:DNA junction so as to leave a ribo A residue from the tRNA at the 5' end of the minus strand. While a single RT heterodimer could in principle catalyze DNA synthesis and primer RNA:DNA bond cleavage, evidence from several in vitro systems suggests that separate RT heterodimers are likely to catalyze these two reactions (Rausch and Le Grice 2004). |
| (summation) | [Reaction:173769] RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers [Homo sapiens] |
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