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Details on Person HIV-1 genomic RNA contains a centrally located PPT (cPPT) wi...
| Class:Id | Summation:177429 |
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| _displayName | HIV-1 genomic RNA contains a centrally located PPT (cPPT) wi... |
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| _timestamp | 2008-06-03 19:07:23 |
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| created | [InstanceEdit:177417] D'Eustachio, P, 2006-03-30 15:26:43 |
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| literatureReference | [Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM
[LiteratureReference:177447] Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase
[LiteratureReference:177435] The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase
[LiteratureReference:182836] 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus
[LiteratureReference:182866] A second origin of DNA plus-strand synthesis is required for optimal Human Immunodeficiency Virus replication |
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| modified | [InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19
[InstanceEdit:188558] D'Eustachio, P, 2006-10-17 19:40:04
[InstanceEdit:352527] D'Eustachio, P, 2008-06-03 19:07:23 |
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| text | HIV-1 genomic RNA contains a centrally located PPT (cPPT) within the pol gene that, like 3'PPT, is spared by RNase H during minus-strand DNA synthesis and persists to prime plus-strand DNA synthesis. This ribonucleotide primes the synthesis of a plus-strand DNA extending through the U3 and R regions of the HIV sequence and terminating in the PBS region (the tRNA primer-binding site). This DNA segment is known as plus-strand strong-stop DNA (+sssDNA) (Telesnitsky and Goff 1997; Pullen et al. 1993; Huber and Richardson 1990). cPPT priming is important for efficient viral replication (Alizon et al. 1992; Rausch and Le Grice 2004). Several features of cPPT priming in vivo remain to be clarified. |
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| (summation) | [Reaction:164513] 3' PPT-primed initiation of plus-strand DNA synthesis [Homo sapiens] |
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