Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person The rate of RNase H cleavage is substantially lower than the...

Class:IdSummation:177427
_displayNameThe rate of RNase H cleavage is substantially lower than the...
_timestamp2006-10-17 19:40:11
created[InstanceEdit:177417] D'Eustachio, P, 2006-03-30 15:26:43
literatureReference[LiteratureReference:182866] A second origin of DNA plus-strand synthesis is required for optimal Human Immunodeficiency Virus replication
[LiteratureReference:177421] Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
[LiteratureReference:177435] The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase
[LiteratureReference:182868] The sequential mechanism of HIV reverse transcriptase RNase H
[LiteratureReference:182873] Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
[LiteratureReference:177447] Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase
modified[InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19
[InstanceEdit:188333] Gopinathrao, G, 2006-10-06 22:15:12
[InstanceEdit:188558] D'Eustachio, P, 2006-10-17 19:40:04
textThe rate of RNase H cleavage is substantially lower than the rate of DNA synthesis (Kati et al. 1992), so the product of the combined DNA synthesis and RNA degradation events catalyzed by the RT heterodimer mediating minus-strand DNA synthesis is a DNA segment still duplexed with extended viral genomic RNA fragments. Other RT heterodimers bind the remaining RNA:DNA heteroduplexes and their RNase H domains further degrade the viral genomic RNA (Wisniewski et al. 2000a, b). Two PPT (polypurine tract) sequence motifs in the template, one immediately 5' to the U3 sequence and one located within the pol gene in the center of the viral genome, are spared from degradation (Charneau et al. 1992; Julias et al. 2004; Pullen et al. 1993).
(summation)[Reaction:182795] RNase H-mediated degradation of the template strand [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by The rate of RNase H cleavage is substantially lower than the... (177427)
Follow Reactome