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Details on Person Phenylacetate and ATP react with coenzyme A to form phenylac...

Class:IdSummation:177140
_displayNamePhenylacetate and ATP react with coenzyme A to form phenylac...
_timestamp2006-03-23 20:05:24
created[InstanceEdit:177120] D'Eustachio, P, 2006-03-23 20:05:02
literatureReference[LiteratureReference:159570] Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids
[LiteratureReference:159552] Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria
[LiteratureReference:177141] Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product
textPhenylacetate and ATP react with coenzyme A to form phenylacetyl CoA, AMP, and pyrophosphate (Vessey et al. 1999). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to phenylacetate metabolism in vivo are unknown.
(summation)[Reaction:177157] phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate [Homo sapiens]
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