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Details on Person UniProt:Q9BRT9 GINS4
| Class:Id | ReferenceGeneProduct:176969 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:1-223 added on Sat February 7 2015;chain:2-223 added on Sat February 7 2015;initiator methionine:1 for 176969 removed on Fri Nov 03 2023;initiator methionine: for 176969 added on Fri Nov 03 2023;initiator methionine: for 176969 removed on Fri Aug 15 2025;initiator methionine:1 for 176969 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BRT9 GINS4 |
| _timestamp | 2025-08-15 21:41:27 |
| chain | chain:1-223 initiator methionine:1 chain:2-223 |
| checksum | 8FAB619A21968BB9 |
| comment | FUNCTION Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).SUBUNIT Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro (PubMed:17170760, PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293, PubMed:32453425). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328).INTERACTION Associates with chromatin.ALTERNATIVE PRODUCTS Significantly up-regulated in aggressive melanomas.MASS SPECTROMETRY This is the measured mass for the GINS complex.SIMILARITY Belongs to the GINS4/SLD5 family. |
| created | [InstanceEdit:176962] Gopinathrao, G, 2006-03-17 19:09:52 |
| description | recommendedName: DNA replication complex GINS protein SLD5 alternativeName: GINS complex subunit 4 component recommendedName: DNA replication complex GINS protein SLD5, N-terminally processed /component |
| geneName | GINS4 SLD5 |
| identifier | Q9BRT9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chromosome Cytoplasm DNA replication Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GINS4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004976] ENSEMBL:ENSG00000147536 GINS4 [Homo sapiens] |
| secondaryIdentifier | SLD5_HUMAN B2R8H5 D3DSY0 Q8N648 |
| sequenceLength | 223 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:356727] UniProt:Q9BRT9-2 GINS4 [Homo sapiens] [ReferenceIsoform:413371] UniProt:Q9BRT9-1 GINS4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:176963] GINS4 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BRT9 GINS4 (176969)
