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Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to
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Details on Person UniProt:Q9YHZ6 cdc45
Class:Id
ReferenceGeneProduct:176966
_chainChangeLog
chain:1-567 added on Fri February 6 2015
_displayName
UniProt:Q9YHZ6 cdc45
_timestamp
2024-08-09 18:50:13
chain
chain:1-567
checksum
A5DE7B8B986429F6
comment
FUNCTION Required for initiation of chromosomal DNA replication. Binds to chromatin in a mutually dependent manner with the GINS DNA replication complex.SUBUNIT Interacts with topbp1 (PubMed:12743046). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (PubMed:30842657, PubMed:30979826).SUBCELLULAR LOCATION Associates with chromatin.SIMILARITY Belongs to the CDC45 family.
