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Details on Person cholesterol + PAPS => cholesterol sulfate + PAP

Class:Id	Reaction:176609
_displayName	cholesterol + PAPS => cholesterol sulfate + PAP
_doRelease	TRUE
_timestamp	2016-11-10 00:54:45
catalystActivity	[CatalystActivity:176510] alcohol sulfotransferase activity of SULT2B1-1 dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:176534] D'Eustachio, P, 2006-03-08 20:43:01
edited	[InstanceEdit:176810] D'Eustachio, P, 2006-03-11 18:40:17
input	[SimpleEntity:158471] PAPS [cytosol] [SimpleEntity:176478] CHOL [cytosol]
literatureReference	[LiteratureReference:176661] Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression [LiteratureReference:176512] Cholesterol sulfate in human physiology: what's it all about? [LiteratureReference:176485] Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase
modified	[InstanceEdit:176811] D'Eustachio, P, 2006-03-11 19:01:00 [InstanceEdit:177298] D'Eustachio, P, 2006-03-27 19:02:00 [InstanceEdit:211329] D'Eustachio, P, 2008-01-31 16:24:38 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	cholesterol + PAPS => cholesterol sulfate + PAP
output	[SimpleEntity:158466] PAP [cytosol] [SimpleEntity:176618] cholesterol sulfate [cytosol]
precedingEvent	[Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS [Homo sapiens] [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359121] R-HSA-176609.3
summation	[Summation:176620] The 3-hydroxyl groups of a number of sterols can undergo sul...
(hasEvent)	[Pathway:156584] Cytosolic sulfonation of small molecules [Homo sapiens]
(precedingEvent)	[Reaction:176606] Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate [Homo sapiens]
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No pathways have been reviewed or authored by cholesterol + PAPS => cholesterol sulfate + PAP (176609)