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Details on Person ATR:ATRIP [nucleoplasm]

Class:IdComplex:176269
_displayNameATR:ATRIP [nucleoplasm]
_timestamp2015-03-23 19:36:18
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
hasComponent
literatureReference[LiteratureReference:176259] ATRIP oligomerization is required for ATR-dependent checkpoint signaling
[LiteratureReference:176171] Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
modified[InstanceEdit:2976659] Jupe, S, 2013-01-10
[InstanceEdit:5684879] Orlic-Milacic, Marija, 2015-03-23
nameATR:ATRIP
ATR-ATRIP
ATM- and rad3-related (ATR)
ATR-interacting protein (ATRIP)
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:369396] R-HSA-176269.1
summation[Summation:176335] The ATR (ATM- and rad3-related) kinase is an essential check...
(activeUnit)[CatalystActivity:5684888] protein serine/threonine kinase activity of ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
[CatalystActivity:5685163] protein serine/threonine kinase activity of ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(hasComponent)[Complex:176281] ATR:ATRIP:RPA:ssDNA signaling complex [nucleoplasm] [Homo sapiens]
[Complex:5684874] ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Homo sapiens]
[Complex:5685178] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Homo sapiens]
[Complex:5686619] ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Homo sapiens]
[Complex:6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] [Homo sapiens]
[Complex:9980013] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Homo sapiens]
[Complex:9980178] ATR:ATRIP:p-RPA:SSB-HHV8 dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Homo sapiens]
(input)[Reaction:176250] Binding of ATR-ATRIP to the RPA-ssDNA complex [Homo sapiens]
[Reaction:5684875] Binding of ATR:ATRIP to RPA at resected DNA DSBs [Homo sapiens]
[Reaction:6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [Homo sapiens]
(output)[BlackBoxEvent:5686663] Completion of SSA [Homo sapiens]
[Reaction:5693561] RAD51 binds BRCA2 at resected DNA DSBs [Homo sapiens]
[Reaction:6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA [Homo sapiens]
(physicalEntity)[CatalystActivity:176203] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]
(updatedInstance)[_UpdateTracker:9878061] Update Tracker - [Complex:176269] ATR:ATRIP [nucleoplasm] - v44:[add_removeHasComponent]
[_UpdateTracker:9892468] Update Tracker - [Complex:176269] ATR:ATRIP [nucleoplasm] - v53:[addName]
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No pathways have been reviewed or authored by ATR:ATRIP [nucleoplasm] (176269)
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